Tesis
Doctoral thesis
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Synthesis of nitrogen containing bioactive compounds using metal catalyzed asymmetric hydrogenation
Chiral drugs
Doctoral student: Martí Sidro Inglés
Research Centre or Institution : IRB Barcelona
Thesis adviser:
Sinopsis
The present doctoral thesis project focuses on the efficient and sustainable preparation of chiral drugs, specifically in the synthesis of chiral amines. Around 40- 45% of drugs in the market contain a chiral amine in their structure. Therefore, the efficient synthesis of these compounds is of vital importance. An ideal methodology for the synthesis of chiral amines is asymmetric hydrogenation. Our laboratory located at the IRB Barcelona has extensive experience in the development of iridium catalysts for asymmetric hydrogenation. The project focuses on the hydrogenation of 3,3-diarylallyl amines, a challenging substrate that poses a significant challenge in the field of asymmetric hydrogenation. The resulting chiral 3,3- diarylpropanamines are important pharmacophores present in various drugs.
In a second stage of the project, we plan to study the synthesis of P-stereogenic ligands, specifically phosphinoquinoline-type ligands. Due to their structural similarity to the original Crabtree catalyst, we anticipate great potential for this new type of catalyst in the asymmetric hydrogenation of alkenes. The effectiveness of these new catalysts will be studied in the hydrogenation of 3,3-diarylallyl amines and other substrates of potential interest.
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Activities related
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21
Sep
2023
Conference Fotones: Herramienta de Frontera para el Avance Científico, Tecnológico, Médico e Industrial Madrid, Thursday, 21 September 2023, 19:00 hours
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4
Oct
2023
Session VII International ALS meeting in Spain: 30 years learning about ALS: new scenarios and challenges Madrid, Wednesday, 4 October 2023, 16:00 hours
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24
Oct
2023
Jornada Científica Online Investigación y avances en antivirales Online, Tuesday, 24 October 2023, 19:00 hours
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- Harnessing microRNAs for cancer immunotherapy 2022 Senior Researcher : Alicia González Martín Research Centre or Institution : Universidad Autónoma de Madrid.
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- Seagrass restoration in the South of the Iberian Peninsula: effective strategies and techniques for the recovery of degraded coastal ecosystems Senior Researcher : África Núñez García de la Morena Research Centre or Institution : Universidad de Málaga
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