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Immediate and universal diagnosis of infectious diseases based on optomechanical capillaries

Infección: alerta precoz, prevención y tratamiento

Investigador Principal: Eduardo Gil Santos

Centro de investigación o Institución: Instituto de Micro y Nanotecnología - CNM - CSIC. Madrid

Abstract

 

Firstly, we carried out precise simulations for calculating the proper dimensions of the optomechanical capillary sensors that will be used throughout the project. The devices should have dimensions between 100 and 200 microns in length, and between 10 and 20 microns in diameter. In addition, they will possess localized microbubbles with diameters between 20 and 30 microns. The capillary wall thickness may not be less than 2 microns. In addition, we assembled a novel experimental system for manufacturing these devices from commercial silica microcapillaries. The manufacturing process consists of 2 steps. The first step consists of heating the commercial microcapillaries by means of a flame in a controlled manner, while they are stretched using micropositioners. This step allows reducing the diameter of the commercial capillaries from the initial 350 microns to a minimum of 6 microns. The second step consists of injecting nitrogen into the microcapillaries, while heating them too, which increases their internal pressure and gives rise to the formation of localized microbubbles having a diameter in between 15 and 50 microns. By regulating the stretching time, the power of the flame, the nitrogen pressure and its injection time, it is possible to control the final dimensions of the devices. Later on, this experimental system has been modified by replacing the flame with a CO2 laser. This system allows controlling the generated heat and its location more precisely, thus, the dimensions of the bubbles generated. Finally, an experimental system has been set up that will allow characterizing the mechanical and optical modes of the sensors, while bacteria flow inside them. The system consists of tunable near-infrared lasers, spectrum analyzers and flow controllers.

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Revista FRA Nº 27

Septiembre 2022 Revista

Enfermedades infecciosas emergentes. Las nuevas pandemias del siglo XXI

Febrero 2013 Monografías Nature

Erradicación y control de las enfermedades producidas por virus

2012 Libros

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