Everyone at a time in our lives, we suffer from stress, it is really a public health problem on the rise, especially at work. Sometimes society sees it as trivial (the term stress has normalized) and forget its serious consequences. Know the two types of stress (eustres and distress) and analyze their evolutionary histor. List and analyze in depth the different sources that cause work stress and the repercussions on the physical and mental health in the bio-psycho-social human being (depression, fatigue, burnout syndrome, psychosomatic syndromes, etc.). To review the greatest discoveries and recent medical researches of the last years of stress as the main protagonist of diseases (early dementias, ICTUS, cancer, etc.). Even the latest advances and the best tools to curb Distres (negative stress). Given the impact and the seriousness of the great ravages of stress, it is good to be aware and start taking measures, even to see it as a disease, let's not forget that stress becomes the cause of a large number of pathologies, and even aggravate the preexisting. It is in this year 2019 when the WHO recognizes the Burnaout Syndrome as a disease. Several preventive techniques are analyzed, collected in the book just published by Dr. Vidal "Work stress Analysis and prevention", useful in companies and at a particular level. Always with positive vision and progress to put the focus of attention to distress, the greatest pandemic of our century.