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New tuberculosis vaccines for the future

Life and Matter Sciences International Symposium October 17-18, 2011 Madrid

General information

Venue: Salón de Actos Fundación Ramón Areces c/ Vitruvio, 5. 28006 Madrid

  • Throughout the Symposium there will be simultaneous translation

Organized by:

Fundación Ramón Areces

Coordinator/s:

Carlos Martín Hospital Universitario Miguel Servet. CIBERES. Universidad de Zaragoza. Spain

Jelle Thole Director TBVI. Netherlands
 

Tuberculosis (TB) is a leading cause of death in the world today. The causative agent of TB, Mycobacterium tuberculosis (MTB), is one of the oldest and world's most devastating human pathogens. A staggering two billion people are latently infected with the bacterium, and according to the WHO, it causes 9.8 million new cases and approximately 1.8 million deaths each year worldwide. The TB pandemic is being driven by the additional complications of the emergence of multidrug-resistant (MDR) and extremely drug resistant (XDR) MTB strains, which are virtually untreatable and the increased mobility of the world's population intensifies the spread of these strains to the industrialized world. Elimination of TB by 2050 is the ultimate goal for Stop TB Partnership. To achieve this goal, faster diagnostics, better drugs and more effective, safe vaccines are urgently needed. Finding new vaccines is particularly important as studies show that without new vaccines TB can never be eliminated. Vaccines will also be especially crucial in combating MDR- and XDR-TB.

No elimination without new vaccines

Bacille Calmette-Guérin (BCG), currently the only available TB vaccine, is widely used and effective in preventing severe forms of TB in children. However, BCG has little to no efficacy in preventing pulmonary TB, the most common and most infectious form of the disease among adults and adolescents worldwide. BCG is also contraindicated for use in immunocompromised patients and newborns with HIV. The world needs new vaccines to replace or improve BCG. These vaccines should also prevent TB in people with latent TB infection (which is not contagious but can still develop into TB later in life) and be safe in people living with HIV.

M. tuberculosis and the host

MTB has evolved complex strategies for intracellular survival and dynamic host-pathogen interplay. Approximately 30% of MTB genome is devoted to lipid biosynthesis or metabolism, which seems to be a useful pre-adaptation to a parasitic existence. Host genetics is important for mycobacterial infectious diseases and in addition population genomics of MTB evolve in order to escape the immune response of the host.

Worldwide efforts are needed

Worldwide, many universities, research institutes and companies work on the development of new vaccines to combat TB. In the past 10 years, particularly European researchers have made tremendous progress in the development of these urgently needed vaccines. Around 40 vaccine candidates are in several stages of development, from basic research to clinical trials.

Objectives

This International Symposium will join scientists and researchers, world leaders in the field of investigation of host-pathogen interactions and new vaccines against TB, to present to the scientific community their efforts and the results of the latest research in vaccines against TB. 

Monday, 17

9:30

Presentation

Raimundo Pérez-Hernández y Torra
Director. Fundación Ramon Areces. Spain.

Julio R. Villanueva
Fundación Ramon Areces. Spain.

Carlos Martín
Jelle Thole 

Coordinators of Symposium. 

Session I: Development of new tb vaccines

Chairmen:
Carlos Martín
Jelle Thole

11:00

11:40

Break

12:20

Innate and Acquired Immune Responses in Tuberculosis: A Vitamin D Connection

Robert Modlin 
School of Medicine at UCLA. California. United States. 

Session II: New tb vaccines in clinical trials 

Chairman:
Paul-Henri Lambert  

Université de Genève. Switzerland.

13:10

The ins and outs of clinical evaluation of TB vaccines

Francois Spertini
Centre Hospitalier Universitaire Vaudois (CHUV). Laussane. Switzerland.

14:00

Break

16:00

BCG trials

Willem Hanekom 
University of Cape Town. South Africa.

Chairman
Juhani Eskola 

National Institute for Health and Welfare. Helsinki. Finland.

16:50

17:30

Pre- and post- exposure vaccines based on recombinant fusion proteins

Else-Marie Agger 
Serum Institut SSI. Copenhagen. Denmark. 

18:10

Break

18:40

19:20

The clinical development of RUTI therapy: a new strategic paradigm combining drugs and vaccines against latent tuberculosis infection

Pere Joan Cardona 
Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol. Badalona. Spain.

Tuesday, 18

Session III: Development of new tb vaccines

Chairman:
Brigitte Gicquel 

Institut Pasteur. Paris. France. 

10:20

HBHA, a latency antigen useful for booster vaccination

Camille Locht  
Institut Pasteur de Lille. Francia.

11:00

Break

Session IV: Preclinical models, production, safety and regulatory issues in tb

Chairman:
Georges Thiry 

PDT- TBVI. France.

13:10

Animal models for new TB vaccine evaluation

Ann Rawkins 
Health Protection Agency. Port Down. United Kingdom.

14:00

Break

Session V: Host-pathogen interactions: the new paradigms (eumednet-tb)

Chairman:
Olivier Neyrolles

CNRS Toulouse. France. 

 

17:10

Evolution & population genomics of Mycobacterium tuberculosis

Sébastien Gagneux  
Swiss Tropical and Public Health Institute. Switzerland.

15:30

Break

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