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New tuberculosis vaccines for the future
Life and Matter Sciences International Symposium October 17-18, 2011 Madrid
General information
Venue: Salón de Actos Fundación Ramón Areces c/ Vitruvio, 5. 28006 Madrid
- Throughout the Symposium there will be simultaneous translation
Organized by:
Fundación Ramón Areces
Coordinator/s:
Carlos Martín Hospital Universitario Miguel Servet. CIBERES. Universidad de Zaragoza. Spain
Jelle Thole Director TBVI. Netherlands
- Description
- Programme
Description
Tuberculosis (TB) is a leading cause of death in the world today. The causative agent of TB, Mycobacterium tuberculosis (MTB), is one of the oldest and world's most devastating human pathogens. A staggering two billion people are latently infected with the bacterium, and according to the WHO, it causes 9.8 million new cases and approximately 1.8 million deaths each year worldwide. The TB pandemic is being driven by the additional complications of the emergence of multidrug-resistant (MDR) and extremely drug resistant (XDR) MTB strains, which are virtually untreatable and the increased mobility of the world's population intensifies the spread of these strains to the industrialized world. Elimination of TB by 2050 is the ultimate goal for Stop TB Partnership. To achieve this goal, faster diagnostics, better drugs and more effective, safe vaccines are urgently needed. Finding new vaccines is particularly important as studies show that without new vaccines TB can never be eliminated. Vaccines will also be especially crucial in combating MDR- and XDR-TB.
No elimination without new vaccines
Bacille Calmette-Guérin (BCG), currently the only available TB vaccine, is widely used and effective in preventing severe forms of TB in children. However, BCG has little to no efficacy in preventing pulmonary TB, the most common and most infectious form of the disease among adults and adolescents worldwide. BCG is also contraindicated for use in immunocompromised patients and newborns with HIV. The world needs new vaccines to replace or improve BCG. These vaccines should also prevent TB in people with latent TB infection (which is not contagious but can still develop into TB later in life) and be safe in people living with HIV.
M. tuberculosis and the host
MTB has evolved complex strategies for intracellular survival and dynamic host-pathogen interplay. Approximately 30% of MTB genome is devoted to lipid biosynthesis or metabolism, which seems to be a useful pre-adaptation to a parasitic existence. Host genetics is important for mycobacterial infectious diseases and in addition population genomics of MTB evolve in order to escape the immune response of the host.
Worldwide efforts are needed
Worldwide, many universities, research institutes and companies work on the development of new vaccines to combat TB. In the past 10 years, particularly European researchers have made tremendous progress in the development of these urgently needed vaccines. Around 40 vaccine candidates are in several stages of development, from basic research to clinical trials.
Objectives
This International Symposium will join scientists and researchers, world leaders in the field of investigation of host-pathogen interactions and new vaccines against TB, to present to the scientific community their efforts and the results of the latest research in vaccines against TB.
Programme
Monday, 17
9:30
Presentation
Raimundo Pérez-Hernández y Torra
Director. Fundación Ramon Areces. Spain.
Julio R. Villanueva
Fundación Ramon Areces. Spain.
Carlos Martín
Jelle Thole
Coordinators of Symposium.
Session I: Development of new tb vaccines
Chairmen:
Carlos Martín
Jelle Thole
10:15
Reflections on an Epic Struggle for Survival: Can Scientists Outwit the Tubercle Bacillus?
Barry Bloom
Harvard University. United States.
11:00
M. tuberculosis: Immunology and evolution
Douglas Young
MRC. Londres. United Kingdom.
11:40
Break
12:20
Innate and Acquired Immune Responses in Tuberculosis: A Vitamin D Connection
Robert Modlin
School of Medicine at UCLA. California. United States.
Session II: New tb vaccines in clinical trials
Chairman:
Paul-Henri Lambert
Université de Genève. Switzerland.
13:10
The ins and outs of clinical evaluation of TB vaccines
Francois Spertini
Centre Hospitalier Universitaire Vaudois (CHUV). Laussane. Switzerland.
14:00
Break
16:00
BCG trials
Willem Hanekom
University of Cape Town. South Africa.
Chairman
Juhani Eskola
National Institute for Health and Welfare. Helsinki. Finland.
16:50
Development of VPM1002, a novel rBCG vaccine, to replace current BCG
Leander Grode
Vakzine Projekt Management. Hannover. Germany.
17:30
Pre- and post- exposure vaccines based on recombinant fusion proteins
Else-Marie Agger
Serum Institut SSI. Copenhagen. Denmark.
18:10
Break
18:40
Boosting BCG with MVA85A: update on clinical trials
Helen McShane
Oxford University. United Kingdom.
19:20
The clinical development of RUTI therapy: a new strategic paradigm combining drugs and vaccines against latent tuberculosis infection
Pere Joan Cardona
Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol. Badalona. Spain.
Tuesday, 18
Session III: Development of new tb vaccines
Chairman:
Brigitte Gicquel
Institut Pasteur. Paris. France.
9:40
10:20
HBHA, a latency antigen useful for booster vaccination
Camille Locht
Institut Pasteur de Lille. Francia.
11:00
Break
11:40
The M. tuberculosis envelope lipids as key molecular players of the modulation of the host immune responses
Germain Puzo
IPBS, CNRS. Toulouse. France.
12:20
Regulation of the immune response in infectious disease
Anne O´Garra
MRC. Mill Hill. United Kingdom.
Session IV: Preclinical models, production, safety and regulatory issues in tb
Chairman:
Georges Thiry
PDT- TBVI. France.
13:10
Animal models for new TB vaccine evaluation
Ann Rawkins
Health Protection Agency. Port Down. United Kingdom.
14:00
Break
16:00
Regulatory issues in the development of novel TB vaccines
Roland Dobbelaer
PDT- TBVI. Belgium.
Session V: Host-pathogen interactions: the new paradigms (eumednet-tb)
Chairman:
Olivier Neyrolles
CNRS Toulouse. France.
16:50
Host genetics and mycobacterial infectious diseases
Ridha Barbouche
Institut Pasteur. Tunisia.
17:10
Evolution & population genomics of Mycobacterium tuberculosis
Sébastien Gagneux
Swiss Tropical and Public Health Institute. Switzerland.
15:30
Break
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