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Mechanisms of neurotrophic factors in health and disease
Life and Matter Sciences International Symposium March 14-15, 2013 Salamanca
General information
Salón de Actos del Instituto de Neurociencias de Castilla y León C/ Pintor Fernando Gallego, 1 37007 Salamanca
Organized by:
Fundación Ramón Areces
Coordinator/s:
Juan Carlos Arévalo Instituto de Neurociencias de Castilla y León. Universidad de Salamanca. Spain
Moses V. Chao Skirball Institute for Biomolecular Medicine. New York University. EE.UU.
- Programme
- Description
Programme
Thursday, 14
9:00
Opening ceremony
José María Medina
Scientific Council. Fundación Ramón Areces. Spain.
Mª Ángeles Serrano
Vice-chancellor of Research. Universidad de Salamanca. Spain.
Raquel Rodríguez
Directora. INCyL. Salamanca. Spain.
Juan Carlos Arévalo
Moses V. Chao
Coordinators of the Symposium.
Session I: Mechanisms of neurotrophic factor actions
Chairwoman:
Lisa Monteggia
University of Texas Southwestern Medical Center. Dallas. EE.UU.
9:30
Convergence of BDNF and glucocorticoid signaling mechanisms
Moses V. Chao
Skirball Institute for Biomolecular Medicine.
New York University. USA.
10:15
Endoreduplication and tetraploidy in vertebrate neurons: regulation by neurotrophins
José María Frade
Instituto Cajal. Madrid. Spain.
11:00
Break
11:30
Dissecting TrkB Receptor isoforms role in BDNF signaling
Lino Tessarollo
Frederick National Lab. Frederick. USA.
12:15
Neurotrophins and adult neural stem cells meet at the neurovascular niche
Isabel Fariñas
Universidad de Valencia. Spain.
13:00
Break
Session II: Neurotrophic factors and disease
Chairman:
Lino Tessarollo
Frederick National Lab. Frederick. USA.
15:00
Regulation of appetite by neurotrophins and beyond
John Lin
Rinat, Pfizer Inc. South San Francisco. USA.
15:45
BDNF and the regulation of central feeding circuits
Maribel Ríos
Tufts University School of Medicine. Boston. USA.
16:30
Break
17:00
Mechanism of rapid antidepressant action
Lisa Monteggia
University of Texas Southwestern Medical Center. Dallas. USA.
17:45
BDNF levels and deregulation of local translation in Down's syndrome
María Luz Montesinos
Universidad de Sevilla. Spain.
Friday, 15
Session III: Neurotrophic factors in plasticity and pain
Chairman:
Moses V. Chao
9:00
Neuregulin/ErbB4 function in cortical interneuron wiring
Beatriz Rico
Instituto de Neurociencias. CSIC-Universidad Miguel Hernández. Alicante. Spain.
9:45
Neurotrophic plasticity in the oculomotor system
Ángel Pastor
Universidad de Sevilla. Spain.
10:30
Break
11:00
Taking pain out of NGF to improve its therapeutic window
Antonino Cattaneo
European Brain Research Institute. Roma. Italy.
11:45
Modulation of NGF functions through TrkA ubiquitination
Juan Carlos Arévalo
INCyL-Universidad de Salamanca. Spain.
12:30
Break
Session IV: Neurotrophic factors as therapeutical tools
Chairwoman:
Maribel Ríos
Tufts University School of Medicine. Boston. USA.
15:00
BDNF is a key modulator of the pathophysiology of Huntington's disease: a therapeutic approach
Jordi Alberch
Universidad de Barcelona. Spain.
15:45
5 Neurotrophic factors in Neuroscience: possible applications in neurodegenerative disorders
Beatriz Moreno
Hospital Clínic de Barcelona. Spain.
16:30
Conclusions
Moses V. Chao
Juan Carlos Arévalo
Description
Neurotrophins are growth factors that include nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin 4/5 (NT-4/5), which are involved in the correct development and functioning of the nervous system. During development, neurotrophins play crucial roles in neuronal survival, proliferation, differentiation and axonal growth whereas in adulthood they modulate higher order functions and circuits that underlie synaptic transmission and plasticity and metabolism. In addition, they have been implicated in different human pathologies, such as pain insensitivity, obesity, neuropsychiatric disorders, mood disorders, depression, bipolar disease and schizophrenia, as well as neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases.
This International Symposium will bring together a diverse panel of leading international and national scientists to discuss new discoveries and novel therapeutic strategies involving neurotrophins and their receptors. Among the topics that will be addressed at this conference are those related with the role of neurotrophic factors in nervous system development, depression, Huntington's disease, obesity, pain and motor neuron disease. This Symposium will provide new insights and new ideas that will facilitate the application of neurotrophin biology to health and disease.
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