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Cancer Immune Escape: Implications for Immunotherapy
Life and Matter Sciences International Symposium October 3-5, 2011 Granada-Dilar
General information
Venue: Salón de Actos Hotel Zerbinetta Pago de la Laguna, 3 18152 Dilar (Granada)
Organized by:
Fundación Ramón Areces
Coordinator/s:
Federico Garrido Hospital Universitario Virgen de las Nieves. Universidad de Granada. Spain
Natalia Aptsiauri Hospital Universitario Virgen de las Nieves. Granada. Spain
- Description
- Programme
Description
Over the past decade, progress in the understanding of tumor biology and immunology has offered the exciting possibility of treating a malignant disease with vaccines that exploit the capacity of T cells to effectively and selectively kill tumor cells. However, cancer still remains a deadly disease with high resistance to therapy and sophisticated mechanisms of evasion from the immune system. This conference will focus on new insights into the molecular mechanisms of cancer immune escape and the complexity of the interactions between host and tumor. New achievements in this field will enable a more rational design of anti-tumor therapies and may help not only explain disease recurrence, but also identify potential targets for therapeutic interventions.
The main goal of this meeting is to bring together leading basic researchers and clinical investigators in the field of cancer immunology to discuss the latest achievements in understanding of anti-tumor immunity, including the role of tumor-associated antigens, the mechanisms of tumor immune escape, new experimental tumor models, the latest results of clinical trials, and future developments in cancer immunotherapy.
We are honored to receive a financial and organizational support form the Fundacion Ramon Areces. We would like also to express our gratitude to the city of Dilar, a small town near Granada, where in Hotel Zerbinetta the meeting will take place.
Programme
Monday, 3
9:00
Welcome
Julio R. Villanueva
Fundación Ramon Areces. Spain.
Federico Garrido
Coordinator of Simposio.
Chairman:
Rolf Kiessling
Department of Oncology and Pathology Cancer Center. Karolinska Institutet. Stockholm. Sweden.
9:30
The molecular basis of cancer immunoediting
Robert Schreiber
Department of Pathology and Immunology. Washington University School of Medicine. St. Louis. United States.
10:15
Overcoming the tumor endothelial barrier for immunotherapy of cancer
Günter J. Hämmerling
Division of Molecular Immunology. Deutsches Krebsforschungszentrum. Heidelberg. Germany.
11:00
Break
Chairman:
Graham Pawelec
Center for Medical Research. University of Tubingen. Germany.
11:30
The role of stroma in immune recognition and destruction of well-established solid tumors
Hans Schreiber
Department of Pathology. University of Chicago. United States.
12:15
Targeting the tumor microenvironment for improving immunotherapy
Michael Shurin
Department of Pathology. University of Pittsburgh School of Medicine. United States.
13:00
The immune response to sporadic antigenic cancer
Thomas Blankenstein
Max-Delbrück-Center for Molecular Medicine (MDC). Berlin. Germany.
14:00
Break
Chairman:
Francesco Marincola
Infectious Disease and Immunogenetics Section. Department of Transfusion Medicine. Clinical Center of the National Institutes of Heath in Bethesda. Maryland. United States.
16:0
The immune escape of cancer: MHC expression and tumor rejection
Federico Garrido
16:45
Novel insights into the modulation of MHC class I antigen processing molecules in tumors
Barbara Seliger
Martin-Luther-Universitaet Halle-Wittenberg. Institute of Medical Immunology. Halle (Saale). Germany.
17:30
Strategies to overcome immune escape by tumor cells
Soldano Ferrone
Department of Immunology. University of Pittsburgh School of Medicine. United States.
18:15
Tuesday, 4
Chairman:
Barbara Seliger
9:00
Melanoma as a model to understand the patho-physiology of rejection
Francesco Marincola
9:45
Numbers and functions of T lymphocytes in human melanoma metastases
Pierre G. Coulie
De Duve Institute. Université Catholique de Louvain. Bruxelles. Belgium.
10:45
Break
Chairman:
Thomas Blankenstein
11:15
12:00
Epigenetic remodeling of cancer cells: a novel strategy to counteract tumor immune escape
Michele Maio
Division of Medical Oncology and Immunotherapy. Department of Oncology. Istituto Toscano Tumori. Ospedaliera Universitaria Senese. Siena. Italy.
12:45
The regulation of NKG2D ligands in melanoma
Annette Paschen
University Hospital Essen. Germany.
14:00
Break
Chairman:
Pierre Coulie
16:00
Immunotherapy of established lesions caused by High Risk Human Papillomavirus
Kees Melief
ISA Pharmaceuticals. Leiden University Medical Center. Netherlands.
16:45
Overcoming immunosuppressive melanoma microenvironment
Victor Umansky
German Clinical Cooperation Unit Dermato-Oncology. German Cancer Research Center. Heidelberg. Germany.
17:30
Cytokine gene transfer for cancer treatment
Gloria González-Aseguinolaza
Centro de Investigación Médica Aplicada (CIMA). Pamplona. Spain.
18:15
Interferon gamma mediated tumor immune escape via numerous mechanisms
Esteban Celis
H. Lee Moffitt Cancer Center and Research Institute. Tampa, FL. United States.
Wednesday, 5
Chairman:
Annette Paschen
9:00
A novel category of tumor antigens enable CTL immunity to tumor escape variants
Thorbald van Hall
Clinical Oncology. Leiden University Medical Center. Leiden. Netherlands.
9:45
Immunoediting of microsatellite-unstable colorectal cancer
Matthias Kloor
German Cancer Center (DKFZ). Heidelberg. Germany.
10:30
Gene therapy of HLA-class I-negative tumors
Natalia Aptsiauri
11:15
Break
11:30
Poster session
12:30
Closing Remarks
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