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Projects. Life and Earth Sciences

Development of therapeutic compounds based on the molecular interaction sites between the A238L viral protein and the transcriptional complexes that regulate the synthesis of pro-inflammatory and tumor mediators.

Lead Researcher: Yolanda Revilla Novella
Research Centre: Centro de Biología Molecular Severo Ochoa. CSIC-UAM. Madrid.

Abstract: 

Yolanda Revilla NovellaIn the past, most drugs were identifying the active principle of traditional remedies or by random discovery. A new approach is to know the molecular basis of the disease, discovering a gene, a molecular mechanism or an "interactoma", related to the origin of the disease. This allows to identify specific targets, from which, using the virtual screening of chemyothecas, select a hit that constitutes the starting point until obtaining a series of candidates on which to work in the preclinical phases. One of the objectives in this project is to evaluate the role of a therapeutic target in inflammation and cancer of the A238L interaction site, mimicking the molecular mechanism of the viral protein, which we have shown to behave as a general inhibitor of transactivation inducible and has already given way to a functional hit in the mouse that we intend currently to develop. Using a similar strategy and since A238L interacts with transcription factors involved in inducible transcription modulating proinflammatory mediators, we intend to find possible therapeutic molecular targets mimicking new functional interaction sites of this protein.

We believe that this strategy will enable, through the application of virtual screening techniques, followed by techniques of medical chemistry and experiments in cellular and mouse models, the discovery of new anti-inflammatory and anti tumorals compounds whose mechanism of action is similar to that of viral protein A238L, a true viral "bonafide".


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