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Projects. Life and Earth Sciences

Modulation of exosomes transporting miRNAs and lncRNAs for intercellular communication as therapeutic tools in dyslipidemia treatment

Lead Researcher: Alberto Dávalos Herrera
Research Centre: Instituto Madrileño de Estudios Avanzados (IMDEA) en Alimentación. Madrid.

Abstract:  

Alberto Dávalos HerreraExosomes are nanovesicles secreted to the extracellular space and involved in intercellular communication, and that are associated with different physiological and pathological processes. Therefore, their modulation has tremendous therapeutic potential as well as for diagnosis purposes. Dietary excess is the main cause of dyslipidemia and cardiovascular disease (CVD). Postprandial lipemia is a residual risk factor that contributes to CVD. The role of exosomes in postprandial lipemia is completely unknown. Moreover, recent studies suggest that some dietary bioactive components may modify the secretion of exosomes. As exosomes contain a lipid bilayer originated from the cell membranes, and these lipids are influenced by the lipids in our diet, we hypothesized that through our diet we could modulate the secretion of exosomes and/or modulate their cargo for therapeutic purposes against dyslipidemia. Thus, the major aim of this proposal is to validate and characterize exosomes that transport miRNAs and lncRNAs in conditions of postprandial lipemia and characterize their mechanisms of action in the context of lipid metabolism. In addition, as proof of concept, we will determine the therapeutic modulation of exosomes through a nutritional intervention aimed to change the composition of the lipids of their membrane and thus alter their cargo and/or secretion. Our experimental approaches will provide therapeutic alternatives for the modulation of exosome secretion and thus contribute to regulate intercellular communication as a therapeutic tool against dyslipidemia and CVD.


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